- Preparation method of 4 - bromo -2 - (difluoromethyl) -5 - methylpyridine
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The invention belongs to the technical field of medical intermediates, and particularly relates to a preparation method of 4 - bromo -2 - (difluoromethyl) -5 - methylpyridine. The compound A is used as a raw material and is sequentially subjected to oxidation reaction, nitration reaction, substitution reaction, reduction reaction, hydrolysis reaction, oxidation reaction and fluoro reaction to prepare 4 - bromo -2 - (difluoromethyl) -5 - methylpyridine, and the prepared 4 -bromo -2 - (difluoromethyl) -5 -5 - 4 -methylpyridine is high in yield and high in purity -2 .
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- HETEROCYCLIC METHYL SULFONE DERIVATIVE
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Provided is a compound capable of inhibiting production or secretion of β amyloid protein. A compound represented by the following formula (1): (wherein, R1 represents a heterocyclic group which may have a substituent, R2 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R3 represents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, R4 represents a hydrogen atom or a C1-6 alkyl group, and X represents -S-,-SO- or -SO2-) an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.
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Page/Page column 143
(2010/11/08)
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