- A convenient regiospecific synthesis of isothiazol-4-yl derivatives
-
Synthesis of derivatives resulting from the formation of a carbon-carbon bond in 4-position of the isothiazole is easily obtained by using the 4-magnesioisothiazole prepared via metal halogen exchange.
- Guilloteau,Miginiac
-
-
Read Online
- RESORCINOL N-ARYL AMIDE COMPOUNDS, FOR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS
-
A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: Y is –CONR1- or optionally substituted arylene or optionally substituted heteroarylene; R1 is H, Cl, F, CH3 or CF3; 10 each R4 is independently H, CH3 or F; R5 is H or CH3; and each R2 and R6 is independently (Alk)n-Rn-(Alk)n-Rn-(Alk)n-X; The compounds of the invention are useful as resorcinol N-aryl amide (NAA) compounds, which are suitable for use as PDK inhibitors, for example for 15 inhibition of cancer cell proliferation.
- -
-
Page/Page column 74
(2015/04/15)
-
- TRIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS
-
Beta-carboline derivatives of structural formula (I) are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
- -
-
Page/Page column 39
(2010/05/14)
-
- BENZAZEPIN-2(1H)-ONE DERIVATIVES
-
Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.
- -
-
Page/Page column 52
(2008/06/13)
-