Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: Design, synthesis, and structural characterization
Hydroxyethylene sulfones were developed as novel scaffolds against aspartyl proteases. A diastereoselective synthesis has been established to introduce the required side chain decoration with desired stereochemistry. Depending on the substitution of the h
Specker, Edgar,B?ttcher, Jark,Heine, Andreas,Sotriffer, Christoph A.,Lilie, Hauke,Schoop, Andreas,Müller, Gerhard,Griebenow, Nils,Klebe, Gerhard
p. 6607 - 6619
(2007/10/03)
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