- A drospirenone and intermediate preparation method (by machine translation)
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The invention discloses a drospirenone and intermediate preparation method. Preparation method of this invention comprises the following steps: in the solvent, the compound 3 with hydrogen peroxide oxidation reaction shown below, to obtain compound 4 can be. Preparation method of this invention does not use a heavy metal reagent, reduces the toxicity of the preparation process, the use of the reagent are all conventional reagent, low cost, and is favorable for industrial large-scale production. (by machine translation)
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Paragraph 0088-0090
(2019/11/20)
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- A PROCESS FOR PREPARING DROSPIRENONE AND INTERMEDIATE THEREOF
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The present invention encompasses processes for preparing drospirenone and intermediates thereof.
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Page/Page column 17
(2009/01/20)
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- A process for the preparation of drospirenone
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A process is described for preparing drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for the preparation of pharmaceutical compositions with contraceptive action, starting from 5,6β-epoxy-7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one.
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Page/Page column 4; 9-10; 15
(2010/02/13)
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- Process for the preparation of drospirenone
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A process is described for preparing drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for the preparation of pharmaceutical compositions with contraceptive action, starting from 5,6beta-epoxy-7beta-hydroxy-15beta,16beta-methylene-3beta-pivaloyloxy-5beta-androstan-17-one.
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Page/Page column 7
(2008/06/13)
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