- 6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepines derivatives as histamine H4 receptor ligands
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The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.
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Page/Page column 76
(2016/03/06)
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- IDO inhibitors
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Presently provided are compounds according to the formula (I) or (II), and pharmaceutical compositions comprising the compounds, wherein R1, R4, and R5 are defined herein. Such compounds and compositions are useful for mod
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Page/Page column 204-205
(2015/11/27)
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- Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides
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A simple and direct synthesis of functionalized imidazoles from α-nitro-epoxides and amidines was developed. This reaction could proceed smoothly in a highly efficient and eco-friendly manner in moderate to excellent yields. A plausible mechanism has also
- Guo, Xiao,Shao, Jiaan,Liu, Huan,Chen, Binhui,Chen, Wenteng,Yu, Yongping
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p. 51559 - 51562
(2015/06/25)
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- Synthesis of 5-arylhistidines via a Suzuki-Miyaura cross-coupling
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Microwave irradiation efficiently promoted the Suzuki-Miyaura reaction of a 5-bromohistidine with various arylboronic acids in the presence of a palladium catalyst. This methodology allowed the synthesis of histidines substituted at position 5 of the imid
- Cerezo, Vanessa,Afonso, Ana,Planas, Marta,Feliu, Lidia
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p. 10445 - 10453
(2008/02/12)
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- Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives: new classes of dopamine receptor subtype specific ligands
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Disclosed are compounds of the formula: wherein R1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R3 and R4 are organic or inorganic substitutents which may togther form ring structutes; m is zero, one or two; and R5 and R6 are are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.
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- Synthesis of Some Alkyl- and Arylimidazoles
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The pyrolysis of 2-azidopyrazines led to give 1-cyanoimidazoles, which were hydrolyzed in alkaline and acidic media to the corresponding imidazoles.This ring transformation occured also by photolysis.
- Watanabe, T.,Nishiyama, J.,Hirate, R.,Uehara, K.,Inoue, M.,et al.
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p. 1277 - 1281
(2007/10/02)
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