SUBSTITUTED PYRAZINYL AMIDE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
Certain substituted pyrazinyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
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Page/Page column 9
(2009/05/28)
Studies on Pyrazines. 7 (1). The Synthesis of 5-Chloropyrazinecarboxylic Acid
The titled carboxylic acid (1) was prepared by condensation of 2-furylglyoxal with aminoacetamide followed by chlorination of the resulting 2-hydroxy-5-(2'-furyl)pyrazine (2) and permanganate oxidation.The acid was further converted into methyl ester and 5-hydroxypyrazinecarboxylic acid.
Sato, Nobuhiro,Arai, Shinji
p. 407 - 408
(2007/10/02)
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