SYNTHESIS OF DES-N-TETRAMETHYLTRIOSTIN A FROM C-TERMINAL Z-D-SERINE TETRA- AND OCTADEPSIPEPTIDE INTERMEDIATES
Des-N-tetramethyltriostin A (1), a known DNA-intercalation agent, has been synthesized from tetra- and octapeptide intermediates that have Z-D-serine at the C-terminal position.The procedure thus allows the fragment coupling and cyclization reactions lead
Dhaon, Madhup K.,Gardner, Joseph H.,Olsen, Richard K.
p. 57 - 62
(2007/10/02)
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