- A water-soluble enhancer, a method for improving the water soluble, and, a method for preparing aq.
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PROBLEM TO BE SOLVED: To provide a water solubility enhancer, a water solubility enhancement method, and an aqueous solution preparation method.SOLUTION: 4"Me-EGCg, 4"Me-GCg, 4"Et-EGCg, or 4"Et-GCg is used as a water solubility enhancer for enhancing solu
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Paragraph 0028; 0029
(2019/09/06)
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- Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol
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An efficient and versatile synthetic method for labile polyphenols was established using 2-nitrobenzenesulfonate (Ns) as a protecting group for phenol. This methodology provides regio-and stereoselective access to a range of methylated catechins, such as methylated epigallocatechin gallates, that are not readily available from natural sources. In addition, biomimetic synthesis of theaflavins from catechins was accomplished using Ns protection to minimize undesired side reactions of electron-rich aromatic rings during oxidation, enabling construction of the complex benzotropolone core in a single-step oxidative coupling reaction. Availability of these compounds will aid detailed structure-biological activity relationship studies of catechins.
- Asakawa, Tomohiro,Kawabe, Yusuke,Yoshida, Atsushi,Aihara, Yoshiyuki,Manabe, Tamiko,Hirose, Yoshitsugu,Sakurada, Asuka,Inai, Makoto,Hamashima, Yoshitaka,Furuta, Takumi,Wakimoto, Toshiyuki,Kan, Toshiyuki
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p. 299 - 312
(2016/05/09)
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- Purification and characterization of a novel O-methyltransferase from Flammulina velutipes
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An enzyme catalyzing the methylation of phenolic hydroxyl groups in polyphenols was identified from mycelial cultures of edible mushrooms to synthesize O-methylated polyphenols. Enzyme activity was measured to assess whether methyl groups were introduced
- Kirita, Masanobu,Tanaka, Yoshihisa,Tagashira, Motoyuki,Kanda, Tomomasa,Maeda-Yamamoto, Mari
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p. 806 - 811
(2015/07/20)
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- Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group
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Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally
- Aihara, Yoshiyuki,Yoshida, Atsusi,Furuta, Takumi,Wakimoto, Toshiyuki,Akizawa, Toshifumi,Konishi, Motomi,Kan, Toshiyuki
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supporting information; experimental part
p. 4171 - 4174
(2010/04/26)
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- Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins
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The regiospecific and enantioselective syntheses of various methylated regioisomers of epicatechin gallate (EGC) and epigallocatechin gallate (EGCG) have been achieved.
- Wan, Sheng Biao,Ping Dou,Chan, Tak Hang
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p. 5897 - 5904
(2007/10/03)
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