- Synthesis of 2-Hydroxy-2′-aroyl-1,1′-biaryls via Oxidative Ring-Opening of 9 H-Fluoren-9-ols
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An Oxone-mediated oxidative ring-opening reaction of 4,5-disubstituted 9H-fluoren-9-ols by cleavage of a carbon-carbon bond is reported. 2-Hydroxy-2′-aroyl-1,1′-biaryls can be efficiently prepared by simply heating the mixture of fluoren-9-ols, Oxone, and 1,1,1,3,3,3-hexafluoroisopropanol at 60 °C for 4 h. The persulfate-involved ring-expansion processes were proposed and supported by the DFT calculations.
- Xue, Xiaoping,Hong, Biqiong,Feng, Jia,Gu, Zhenhua
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p. 496 - 500
(2022/01/20)
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- Oxidative Kinetic Resolution of Cyclic Benzylic Ethers
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A manganese-catalyzed oxidative kinetic resolution of cyclic benzylic ethers through asymmetric C(sp3)?H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the α position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.
- Liu, Lei,Liu, Ziqiang,Ma, Yingang,Sun, Shutao
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supporting information
p. 176 - 180
(2020/10/30)
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- Synthesis of dibenzopyranones and pyrazolobenzopyranones through copper(0)/Selectfluor system-catalyzed double C[sbnd]H activation/oxygen insertion of 2-arylbenzaldehydes and 5-arylpyrazole-4-carbaldehydes
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A mild and efficient protocol for the synthesis of dibenzopyranones and pyrazolobenzopyranones was developed involving a copper(0)/Selectfluor system-catalyzed double C[sbnd]H activation/oxygen insertion of 2-arylbenzaldehydes and 5-arylpyrazole-4-carbaldehydes. Preliminary mechanistic studies suggest that both water and dioxygen act as the oxygen source in the formation of pyranone scaffolds.
- Zhang, Jian,Shi, Dongdong,Zhang, Haifeng,Xu, Zheng,Bao, Hanyang,Jin, Hongwei,Liu, Yunkui
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p. 154 - 163
(2016/12/23)
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- 6-Aryldibenzo[b,d]pyrylium salts: Synthesis and characterization of a reversible pH-driven optical and spectroscopic response
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This preliminary report describes the synthesis of three 6-aryldibenzo[b,d]pyrylium salts, a relatively unexplored structural unit. The optical and spectroscopic properties of the 6-aryldibenzo[b,d]pyrylium salts were examined as a function of pH. All thr
- Prust, Erin E.,Carlson, Erik J.,Dahl, Bart J.
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p. 6433 - 6435
(2013/01/15)
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- 6-Substituted 6H-dibenzo[b,d]pyran derivatives and process for their preparation
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The present invention relates to new 6-substituted 6H-dibenzo [b,d]pyran derivatives, to a process for their preparation and pharmaceutical and veterinary compositions containing them.
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