TRANSLOCATION CONTROL ELEMENTS, REPORTER CODES, AND FURTHER MEANS FOR TRANSLOCATION CONTROL FOR USE IN NANOPORE SEQUENCING
Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocati
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Paragraph 00171
(2020/12/07)
P-Stereodefined phosphorothioate analogs of glycol nucleic acids—synthesis and structural properties
Enantiomerically pure, protected acyclic nucleosides of the GNA type (glycol nucleic acids) (GN′), obtained from (R)-(+)- and (S)-(?)-glycidols and the four canonical DNA nucleobases (Ade, Cyt, Gua and Thy), were transformed into 3′-O-DMT-prote
Tomaszewska-Antczak, Agnieszka,Jastrz?bska, Katarzyna,Maciaszek, Anna,Miko?ajczyk, Barbara,Guga, Piotr
p. 24942 - 24952
(2018/07/29)
Solid phase synthesis is solid including the fluorine reagent and its application
The present invention provides a fluorine-containing solid-phase synthesis reagent and an application thereof. Specifically the present invention provides a fluorine-containing compound capable of being adopted as a nucleic acid monomer, wherein the compo
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Paragraph 0185-0187
(2018/01/19)
OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
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Page/Page column 220; 221
(2015/02/02)
Synthesis of glycol nucleic acids
Starting from glycidol, the synthesis of dimethoxytritylated glycol nucleoside phosphoramidites of adenine (A), thymine (T), uracil (U), guanine (G), and cytosine (C) is reported. These phosphoramidites are the building blocks for the automated solid phas
Zhang, Lilu,Peritz, Adam E.,Carroll, Patrick J.,Meggers, Eric
p. 645 - 653
(2007/10/03)
Glycerol nucleoside triphosphates: Synthesis and polymerase substrate activities
The synthesis of (S)-glycerol nucleoside triphosphates (gNTPs) and the analysis of their substrate activities for enzymatic polymerization is described. NTPs with simplified carbohydrate backbones such as the tNTPs (α-L-threose-NTPs) are polymerase substr
Horhota, Allen T.,Szostak, Jack W.,McLaughlin, Larry W.
p. 5345 - 5347
(2007/10/03)
Synthesis of propane-2,3-diol combinatorial monomers
Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroaryl-propane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis.
Acevedo, Oscar L.,Andrews, Robert S.
p. 3931 - 3934
(2007/10/03)
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