Process for the preparation of (4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydropyran-2-one
The present invention relates to an improved, efficient and enantio-selective process for the synthesis of (4R, 6S)-4-hydroxy-6-hydroxymethyl tetrahydropyran-2-one, employing the Sharpless asymmetric dihydroxylation and regiospecific nucleophilic hydride opening of the cyclic sulfite/sulfate as the key steps. The invention also resides in the intermediates used in the process.
-
(2008/06/13)
Vicinal Diol Cyclic Sulfates: Like Epoxides Only More Reactive
-
Gao, Yun,Sharpless, K. Barry
p. 7538 - 7539
(2007/10/02)
Further Synthesis of Optically Active Verrucarinic Acid
Two new syntheses of verrucarinic acid ((2S,3R)-2,5-dihydroxy-3-methylpentanoic acid) and its derivatives, suitably protected for the further conversion to macrocyclic trichothecenes, are described.The first one makes use of a diastereoselective alkylation of a (-)-(S)-malic acid ester and the regioselective reduction of one carboxyl function to a methyl group.The second approach involves a stereoselective addition of an allylsilane to a chiral glyoxylate.
Grossen, Peter,Herold, Peter,Mohr, Peter,Tamm, Christoph
p. 1625 - 1629
(2007/10/02)
More Articles about upstream products of 83541-68-8