The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
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Paragraph 00450-00452
(2019/08/20)
Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase
The Boehringer Ingelheim compound collection was screened for inhibitors of the ATPase activity of human papillomavirus E1 helicase to develop antiviral agents that inhibit human papillomavirus (HPV) DNA replication. This screen led to the discovery of (biphenyl-4-sulfonyl)acetic acid 1, which inhibits the ATPase activity of HPV type 6 E1 helicase with a low micromolar IC50 value. A hit-to-lead exercise rapidly converted 1 into a low nanomolar lead series.
Faucher, Anne-Marie,White, Peter W.,Brochu, Christian,Grand-Ma?tre, Chantal,Rancourt, Jean,Fazal, Gulrez
p. 18 - 21
(2007/10/03)
An Alternative Synthesis of Tiopinac
Tiopinac (1) thiepin-3-acetic acid, (1)> has been shown a high degree of antiinflammatory activity and a low incidence of side effects in animals (2).On the basis of results, Tiopinac was chosen for human evaluation in 1978 (2a).
Thurber, T. Craig,Prince, Anthony,Halpern, Otto
p. 961 - 965
(2007/10/02)
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