- The preparation method of the [...]
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The invention discloses a method for preparing [...], which belongs to the chemical pharmaceutical intermediates preparation method technical field, the use of P-acetonitrile, O-nitro-P-chlorotoluene and 2 - hydroxy - 3, 5 - diiodosalicylic benzoic acid as the raw material, by condensation reaction, the reduction reaction and re-condensation reaction, then in the sodium hydroxide solution the salifiable preparation 2 - (trifluoromethyl) pyridine - 3 - formaldehyde. The method of the invention, adopting a relatively friendly reducing agent to replace the iron powder such as iron and waste water and the like to avoid the emission of pollutants, and simplifying the post-treatment, the improved process simple and safe operation, mild reaction conditions, the product yield is relatively high, less "wastes", has high industrial value.
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Paragraph 0023-0028
(2019/07/04)
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