- PROCEDURE FOR PREPARING A PHARMACEUTICALLY ACTIVE COMPOUND
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The invention relates to a procedure for preparing quetiapine by reaction between a compound of formula (II) and a compound of formula (III), in which X means a leaving group and P a protective group of alcohols resistant to alkaline conditions, in the presence of a base, followed by a step of deprotection and, optionally, obtaining a pharmaceutically acceptable salt thereof. Said procedure permits the obtaining of quetiapine with a high degree of purity under soft temperature conditions, with short reaction times and avoiding the use of toxic solvents.
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Page/Page column 13
(2008/06/13)
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- PREPARATION OF QUETIAPINE
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The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure of a compound of the formula shown below, as well as novel intermediates in the process.
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Page/Page column 9
(2008/06/13)
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- Process for the preparation of a thiazepine derivative
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The present invention relates to a process for the preparation of biologically active thiazepine derivative. The present invention more particularly, relates to an improved process for the preparation of dibenzo[b,f][1,4]thiazepine derivative of formula (I).
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Page/Page column 5; 6
(2010/02/11)
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