Direct, practical, and powerful crossed aldol additions between ketones and ketones or aldehydes utilizing environmentally benign TiCl4-Bu3N reagent
An efficient TiCl4-Bu3N - (cat. TMSCl)-promoted aldol addition between ketones and ketones or aldehydes was performed. This environmentally benign method is advantageous from a green chemical viewpoint with regard to yield, substrate
A highly diastereoselective cross aldol reaction is developed using divalent tin enolates formed from stannous trifluoromethanesulfonate and carbonyl compounds.The reaction is extended to a highly enantioselective cross aldol reaction employing chiral dia
STANNOUS TRIFLATE: A FACILE CROSS-ALDOL REACTION BETWEEN TWO KETONES VIA DIVALENT TIN ENOLATES
Divalent tin enolates, formed from stannous triflate and ketones, react with a second ketone under mild conditions to afford the corresponding cross-aldol products in good to excellent yields.In the case of the cross-coupling with aromatic ketone, enhance