- Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10- iminocyclohept[b]indoles: High-affinity ligands for the N,N'-di-o- tolylguanidine-labeled σ binding site
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A series of 5,6,7,8,9,10-hexahydro-7,10-iminocyclo[b]indoles substituted at the 5 and/or 11 positions was synthesized from tropinone. Affinity for σ binding sites was determined using [3H]-N,N'-di-o-tolylguanidine ([3H]DTG) and [sup
- Mewshaw,Sherrill,Mathew,Kaiser,Bailey,Karbon
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- Bridged γ-Carbolines and Derivatives Possessing Selective and Combined Affinity for 5-HT2 and D2 Receptors
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A series of 5,6,7,8,9,10-hexahydro-7,10-iminocycloheptindoles and 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooctindoles was prepared. Structural modifications of the lead compound, 11--5,6,7,8,9,10-hexahydro-7,10-iminocycl
- Mewshaw, Richard E.,Silverman, Lisa S.,Mathew, Rose M.,Kaiser, Carl,Sherrill, Ronald G.,et al.
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p. 1488 - 1495
(2007/10/02)
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- STEREOCHEMICALLY COMPLEMENTARY REDUCTIONS OF INDOLES
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Indoles containing 2, 3-fused bridged ring undergo highly stereoselective reduction to cis-fused derivatives with the endo-exo stereochemistry depending on choice of reducing agent.
- Berger, Joel G.,Tahbaz, Pirouz,McPhail, Andrew T.,Onan, Kay D.
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p. 2469 - 2472
(2007/10/02)
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- 5 Phenyl-1,3-alkano-1,2,3,4,4a,9b-hexahydropyrido [4,3-b]indoles
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This invention relates to 5-phenyl-1,3-alkano-1,2,3,4,4a,9b-hexahydropyrido [4,3-b]indoles which are antidepressants useful in the treatment of mental depression.
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