- Evidence of acid mediated enhancement of photoinduced charge transfer reaction in 2-methoxy-4-(N,N-dimethylamino)benzaldehyde: Spectroscopic and quantum chemical study
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The photophysical behavior of 2-methoxy-4-(N,N-dimethylamino)benzaldehyde (2-MDMABA) has been investigated by steady state absorption and emission spectroscopy, time resolved emission spectroscopy and quantum chemical calculations. The molecule 2-MDMABA h
- Samanta, Anuva,Paul, Bijan Kumar,Mahanta, Subrata,Singh, Rupashree Balia,Kar, Samiran,Guchhait, Nikhil
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Read Online
- Convergent18F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2Areceptor PET ligands
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Positron emission tomography (PET) investigations of the 5-HT2Areceptor (5-HT2AR) system can be used as a research tool in diseases such as depression, Alzheimer's disease and schizophrenia. We have previously developed a11C-labeled agonist PET ligand ([11C]Cimbi-36), and the aim of this study was to identify a18F-labeled analogue of this PET-ligand. Thus, we developed a convergent radiochemical approach giving easy access to 5 different18F-labeled ligands structurally related to Cimbi-36 from a common18F-labeled intermediate. After intravenous injection, all ligands entered the pig brain. However, since within-scan intervention with ketanserin, a known orthosteric 5-HT2Areceptor antagonist, did not result in significant blocking, the radioligands seem unsuitable for neuroimaging of the 5-HT2AR in vivo.
- Petersen, Ida Nymann,Villadsen, Jonas,Hansen, Hanne Demant,Jensen, Anders A.,Lehel, Szabolcs,Gillings, Nic,Herth, Matthias M.,Knudsen, Gitte M.,Kristensen, Jesper L.
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supporting information
p. 5353 - 5356
(2016/10/22)
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- Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films
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Bisazomethine dyes, which are synthesized using diaminomaleonitrile and aminobenzaldehydes, exhibit red fluorescence in solution and in the solid state. Several bisazomethine dyes are known to form J-aggregates in vapour-deposited films. In this work, novel bisazomethine dyes were synthesized and the effect of phenyl ring substitution on the J-aggregate formation in vapour-deposited films was examined. The optical properties of the dyes were examined in solution and in the solid state through molecular orbital calculations. Four derivatives were found to form J-aggregates in vapour-deposited films as determined from the shape of the spectrum and the absorption edge.
- Kim, Byung-Soon,Kashibuchi, Daisuke,Son, Young-A.,Kim, Sung-Hoon,Matsumoto, Shinya
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experimental part
p. 56 - 64
(2011/12/02)
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- 3-(substituted phenyl)phthalides
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Process comprises the combination of the three steps of condensing 3-N(R)2 -4-X-benzoic acid with an aromatic or heterocyclic aldehyde, Y-CHO, under acidic conditions to produce 3-Y-5-X-6-N(R)2 phthalide (II), condensing said phthalide with a compound of the formula Z-H under alkaline or acid conditions to produce 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acid (III), and oxidizing said benzoic acid to produce 3-Y-3-Z-5-X-6-N(R)2 phthalide (I) where: R is hydrogen, non-tertiary alkyl of one to four carbon atoms, benzyl or substituted benzyl; X is hydrogen or halo; Y is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl, 9-R7 -3-carbazolyl, 9-julolidinyl, 3,4-dioxymethylenephenyl, 2-thienyl, 1-R8 -2-pyrrolyl, or 4-pyridinyl; and Z is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl or 1-R8 -2-pyrrolyl which are useful as colorless precursor color formers in carbonless duplicating and in thermal marking systems. The intermediates, 3-Y-5-X-6-N(R)2 phthalides (II) and 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acids (III) also have utility as colorless precursor color formers in carbonless duplicating and thermal marking systems.
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- N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as Antihypertensive and Diuretic Agents
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The synthesis of a series of N2--2,6-dichlorophenyl>-N1,N1-dimethylformamidines that caused marked blood pressure lowering and/or diuresis in spontaneously hypertensive rats (SHR) is reported.Diuretic activity was not always associated with acute antihypertensive activity.Central nervous system effects, most notably sedation, were observed.Compound 9d, which lowered arterial blood pressure 37 mmHg in SHR when dosed at 100 mg/kg, was further evaluated in chronic hypertensive dogs because of apparent minimal CNS effects.A reduction in arterial blood pressure of 32 mmHg at 1.0 mg/kg during a 6-h postdosing interval was observed.This response was unrelated to α- or β-adrenergic blockade, angiotensin I antagonism, or neuronal or ganglionic blockade.CNS effects were also observed.
- Meyer, Walter E.,Tomcufcik, Andrew S.,Chan, Peter S.,Emma, John E.
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p. 1705 - 1710
(2007/10/02)
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- Novel compounds, processes and marking systems
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Mono and bis substituted (arylsulfonyl)alkanes useful as color formers, particularly in carbonless duplicating and thermal marking systems, are prepared by the interaction of the appropriate aldehyde or dialdehyde with the appropriate aryl or heterocyclic moiety and the appropriate phenylsulfinic acid in the presence of a catalyst.
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