- Chiral ligands and their transition metal complexes
-
The present invention relates to chiral phosphorus compounds and their transition metal complexes, and also to the use of these transition metal complexes, especially in asymmetric syntheses.
- -
-
-
- t-BuOK-mediated hydrophosphination of functionalized alkenes: A novel synthesis of chiral P,N- and P,P-ligands
-
A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-α-(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.
- Bunlaksananusorn, Tanasri,Knochel, Paul
-
p. 4595 - 4601
(2007/10/03)
-
- CHIRAL LIGANDS AND THEIR TRANSITION METAL COMPLEXES
-
The invention relates to chiral phosphorus compounds and their transition metal complexes, in addition to the use of said transition metal complexes, in particular in asymmetric syntheses.
- -
-
Page/Page column 21
(2010/02/09)
-
- New P, N ligands for asymmetric Ir-catalyzed reactions
-
Chiral Ir complexes such as 1 catalyze the hydrogenation of (E)-1, 2-diphenylpropene at 1 bar of H2 to give (5)-1, 2-diphenylpropane with up to 95% ee and full conversion (see scheme). Methyl (Z)-α -(acetamido)cinnamate underwent enantioselective hydrogenation under similar conditions to the corresponding amino acid derivative with up to 96% ee. BARF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate, cod = 1, 5-cyclooctadiene.
- Bunlaksananusorn, Tanasri,Polborn, Kurt,Knochel, Paul
-
p. 3941 - 3943
(2007/10/03)
-
- New Applications of Camphor-Derived P,N-Ligands for Asymmetric Pd- and Ir-Catalyzed Reactions
-
Ir-catalyzed asymmetric hydroboration of bicyclic hydrazine 4 in the presence of chiral ligand 1a, leads to bicyclic alcohol 5 after oxidative workup in good yield (76%) and moderate enantioselectivity (71% ee).
- Bunlaksananusorn, Tanasri,Luna, Alejandro Pérez,Bonin, Martine,Micouin, Laurent,Knochel, Paul
-
p. 2240 - 2242
(2007/10/03)
-
- Enantiomerically pure pyridine and 2,2'-bipyridine thioethers: New N-S chiral ligands for asymmetric catalysis. Palladium-catalyzed allylic alkylation
-
Diastereomeric pure pyridine and 2,2'-bipyridine thioethers, derived from (+)-camphor, were prepared and assessed in the enantioselective palladium-catalyzed allylic substitution of 1,3-diphenylprop-2-enyl acetate with dimethyl malonate. Enantioselectivit
- Chelucci, Giorgio,Culeddu, Nicola,Saba, Antonio,Valenti, And Raffaela
-
p. 3537 - 3546
(2007/10/03)
-