- FLUORINE-CONTAINING THALIDOMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING THE SAME
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PROBLEM TO BE SOLVED: To provide a novel thalidomide three-agents derivative that has a similar structure to those of three thalidomide agents (thalidomide, lenalidomide, pomalidomide) but has oxidative metabolism resistant activity and can avoid teratogenicity. SOLUTION: A fluorinated thalidomide three-agents derivative is represented by the formula (1) (R1, R2, R3 are the same or different to represent H or F, where at least one of R1, R2, R3 is F; R4 is H or an optionally substituted hydroxy, alkoxy, acyl, acyloxy or alkyl group; X is H, F or an optionally substituted amino group; Y is -C(=O)- or -CH2-). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
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Paragraph 0077-0079
(2021/09/29)
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- Preparation method of 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol
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The invention relates to a preparation method of 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol. According to the method, specifically, 2,3-difluorotoluene is adopted as a raw material, and 7,8-difluoro-6,11-dihydro-dibenzothiophene-11-alcohol is e
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- Difluoroalkylaromatics
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The present invention relates to 3,4-difluoro-2-alkylaromatics and 2,4-difluoro-3-alkylaromatics, to a process for their preparation and to their use for preparing active ingredients.
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Page/Page column 4
(2010/02/11)
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