The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.
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Paragraph 0398-0400
(2017/10/26)
Synthesis of 5-Stannylpyrimidines and their Use in Pd-Catalysed Ketone Formation
2-(Dimethyl-t-butylsiloxy)-5-stannylpyrimidines have been prepared from the lithiated pyrimidine precursor. 2-Methylthio-5-stannylpyrimidines were prepared similarly and oxidized chemoselectively to the corresponding sulphones. 5-Stannylpyrimidin-2(1H)-ones can be prepared by fluoride-induced removal of the silyl group in 2-(dimethyl-t-butylsiloxy)-5-stannylpyrimidines, and the 5-stannylated pyrimidinones can be N-alkylated.The stannylated pyrimidines are stable compounds which react readily with acid chlorides in Pd-catalysed reaction with formation of 5-pyrimidinyl ketones.
Arukwe, Joseph,Benneche, Tore,Undheim, Kjell
p. 255 - 259
(2007/10/02)
Organomanganese(II) Reagents in the Synthesis of 5-Pyrimidinyl Ketones
Substituted alkyl 5-pyrimidinyl ketones were formed from acid chlorides of pyrimidine-5-carboxylic acids and alkylmanganese(II) iodides.The corresponding alcohols were also formed in the case of sterically less requiring organomanganese reagents and the a
Arukwe, Joseph,Undheim, Kjell
p. 764 - 767
(2007/10/02)
Enols of 1,1-Diformylacetone in the Synthesis of 5-Acylpyrimidines
The enol acetate of 3-oxobutanal has been formylated using ethyl orthoformate to provide the enol ether of 1,1-diformylacetone.The latter has been condensed with methylisothiourea to yield isomeric 5-acetyl and 4-methyl-5-formyl- pyrimidines, the ratio being dependent on the reaction conditions.
Benneche,Tore,Undheim,Kjell
p. 529 - 532
(2007/10/02)
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