- Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: Aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif
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Biaryl ethers were recently reported as potent NNRTIs. Herein, we disclose a detailed effort to modify the previously reported compound 1. We have designed and synthesized a series of novel pyrazole derivatives as a surrogate for pyrazolopyridine motif th
- Su, Dai-Shi,Lim, John J.,Tinney, Elizabeth,Tucker, Thomas J.,Saggar, Sandeep,Sisko, John T.,Wan, Bang-Lin,Young, Mary Beth,Anderson, Kenneth D.,Rudd, Deanne,Munshi, Vandna,Bahnck, Carolyn,Felock, Peter J.,Lu, Meiquing,Lai, Ming-Tain,Touch, Sinoeun,Moyer, Gregory,Distefano, Daniel J.,Flynn, Jessica A.,Liang, Yuexia,Sanchez, Rosa,Perlow-Poehnelt, Rebecca,Miller, Mike,Vacca, Joe P.,Williams, Theresa M.,Anthony, Neville J.
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scheme or table
p. 4328 - 4332
(2010/09/18)
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- Synthesis of Furan Derivatives. LXXXVIII. Reactivity of Tosylmethyl Isocyanide towards Azole Carbaldehydes
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Tosylmethyl isocyanide (4) reacted readily with azole carbaldehydes, i.e., indole-2-carbaldehyde (8a), pyrazole-3(5)-carbaldehyde (8b), 3(5)-methylpyrazole-5(3)-carbaldehyde (8c), 3(5)-(2-furyl)pyrazole-5(3)-carbaldehyde (8d), 1,2,4-triazole-3(5)-carbalde
- Saikachi, Haruo,Kitagawa, Tokujiro,Sasaki, Hideaki,Leusen, Albert M. van
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p. 4199 - 4204
(2007/10/02)
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