- Palladium-catalyzed decarbonylative C–N coupling to convert arylcarbamoyl chlorides to urea derivatives
-
This paper describes the development of a palladium-catalyzed decarbonylative C–N coupling reaction that transforms arylcarbamoyl chlorides into tetrasubstituted ureas under a nitrogen atmosphere. A broad range of functional groups are compatible with this reaction, and diverse urea derivatives can be obtained with good to high yields.
- Fan, Aihong,Peng, Jinsong,Zhou, Dun,Li, Xiang,Chen, Chunxia
-
supporting information
p. 1 - 12
(2020/07/27)
-
- Organic ligand and solvent free oxidative carbonylation of amine over Pd/TiO2 with unprecedented activity
-
A highly active Pd/TiO2 catalyst system was prepared and applied in the oxidative carbonylation of amines to ureas with ultra-low Pd content under organic ligand and solvent free conditions. The catalytic turnover frequencies (TOFs, moles of amines converted per mole of Pd per h) were 126000 and 250000 h-1 for the production of diphenylurea and dibenzylurea, respectively. An expanded substrate scope including the electron-rich and electron-deficient anilines, primary aliphatic amines, secondary amines was also established. This work offers a straightforward, step economic, and green methodology for the efficient synthesis of valuable ureas.
- Liu, Shujuan,Dai, Xingchao,Wang, Hongli,Shi, Feng
-
supporting information
p. 4040 - 4045
(2019/08/07)
-