- Process for the preparation of a macrocycle
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The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.
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Page/Page column 25
(2010/03/02)
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- NEW RUTHENIUM COMPLEXES AS CATALYSTS FOR METATHESIS REACTIONS
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The invention relates to novel metathesis catalysts of the formula (I) a process for making the same and their use in metathesis reactions such as ring closing or cross metathesis. The invention further relates to a process for the manufacture of a macrocyclic compound of formula (VII) which have the potential to be useful as HCV protease inhibitors.
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Page/Page column 53-54
(2009/11/29)
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- Process for the preparation of a macrocycle
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The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.
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Page/Page column 20-21
(2009/07/10)
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- MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULFONAMIDES AS INHIBITORS OF HCV REPLICATION
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The present invention provides compounds of the general formulas I-IX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The present invention further provides treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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Page/Page column 178
(2008/06/13)
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