- INHIBITORS OF MUTANT ISOCITRATE DEHYDROGENASES AND COMPOSITIONS AND METHODS THEREOF
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The invention provides novel chemical compounds useful for treating cancer, or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
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Paragraph 0094
(2019/02/13)
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- Substituted Spiroamide Compounds
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Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q1, Q2, Q3, Q4, R1, R8, R9a, R9b, R12, R13, R200 and R210 have defined meanings, processes for their preparation, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).
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Page/Page column 39
(2010/09/18)
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- SUBSTITUTED IMIDAZOHETEROCYCLES
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The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.
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Page/Page column 16; 17
(2009/01/24)
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- Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor α (TNF-α) production: Selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3- carbonitriles
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Tumor progression loci-2 (Tpl2) (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family directly upstream of MEK. Recent studies using Tpl2 knockout mice have indicated an important role for Tpl2 in the lipopolysaccharide (LPS) induced production of
- Green, Neal,Hu, Yonghan,Janz, Kristin,Li, Huan-Qiu,Kaila, Neelu,Guler, Satenig,Thomason, Jennifer,Joseph-McCarthy, Diane,Tam, Steve Y.,Hotchandani, Rajeev,Wu, Junjun,Huang, Adrian,Wang, Qin,Leung, Louis,Pelker, Jefferey,Marusic, Suzana,Hsu, Sang,Telliez, Jean-Baptiste,Hall, J. Perry,Cuozzo, John W.,Lin, Lih-Ling
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p. 4728 - 4745
(2008/03/11)
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