cas 851386-34-0, 2,3-Difluoro-4-iodopyridine | Articles data ｜lookchem

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851386-34-0

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INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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Paragraph 00226

(2018/12/03)

Pyridines substituted with five different elements
By stepwise and regioselective installation of functional groups, we have synthesized and characterized two pyridines, 3-fluoro-5-iodo-2-(methylthio)-6-(trimethylsilyl)isonicotinonitrile and 3-fluoro-5-iodo-2-methoxy-6-(trimethylsilyl)isonicotinonitrile,
Vonkieseritzky, Fredrik,Lindstrm, Johan
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p. 63 - 66
(2010/04/26)

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1513-66-2
2,3-difluoropyridine

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Chemical Properties

Melting Point: 66-68 °C
Boiling Point: 212.775 °C at 760 mmHg
Flash Point:82.483 °C
Density: 2.13 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Vapor Pressure: 0.248mmHg at 25°C
Refractive Index: 1.572
PKA: -4.24±0.18(Predicted)
PSA: 12.89000
LogP: 1.96440

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