- Iron-Catalyzed Intramolecular C—H Amidation of N-Benzoyloxyureas
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A redox-neutral Fe-catalyzed intramolecular C—H amidation of N-benzoyloxyureas is described. This methodology employs a simple iron complex in situ generated from Fe(OTf)2 and bipyridine as the catalyst and N-benzoyloxyureas as the nitrene prec
- Zhong, Dayou,Wu, Lin-Yang,Wang, Xing-Zhen,Liu, Wen-Bo
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supporting information
p. 855 - 858
(2021/02/16)
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- Protein–ligand interaction-guided discovery of novel VEGFR-2 inhibitors
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As an effective target in abnormal angiogenesis-related tumor treatment, VEGFR-2 has small-molecule inhibitors of various scaffolds being approved for treating diseases such as renal carcinoma, non-small cell lung cancer, etc. However, endogenous and acqu
- Zhang, Yanmin,Zhang, Mingliang,Wang, Yuchen,Fan, Yuanrong,Chen, Xingye,Yang, Yan,Hua, Yi,Xie, Wuchen,Lu, Tao,Tang, Weifang,Chen, Yadong,Liu, Haichun
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p. 2559 - 2574
(2019/07/12)
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- METHODS OF USING SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS
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Methods of using semi-synthetic glycopeptides of formula I-XIV having antibacterial activity are described.
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Page/Page column 99; 100
(2011/11/30)
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- 1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES
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The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.
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Page/Page column 80
(2010/02/12)
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- (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them
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3-(Phenylalkylaminoalkylozy)-heteroaryl compounds having heart rate lowering and/or anti-ischemic effects, methods for their preparation and pharmaceutical compositions containing them are described. The compounds correspond to the general formula I STR1 or to the general formula XXXI STR2 in which the substituents have the meanings given the specification.
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- Studies on Ca2+ channel antagonists. A 2-diazo-3,3,3-trifluoropropionamide derivative related to verapamil as a potential photoaffinity probe.
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2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-[N-[4-(N-methyl-2-diazo- 3,3,3-trifluoropropionamido)phenethyl]methyl-amino]valeronitril e (3), a potential photoaffinity probe for Ca2+ channels related to verapamil (1), was prepared from N-methyl-4-nitrophenethylam
- Theodore,Nelson,Dave,Giacomini
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p. 873 - 877
(2007/10/02)
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