- MC - 1568 Synthesis method
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The invention provides a synthesis method of MC-1568. The preparation method comprises the steps as follows: step 1, tetrahydrofuran, triethyl phosphonoacetate and potassium tert-butoxide are stirredat the room temperature, a suspension of N-methylpyrrole-2-formaldehyde and tetrahydrofuran is added, the reaction solution is stirred, water is added after the reaction, ethyl acetate is added, the mixed solution is stirred and left to stand for layering, a water layer is extracted with ethyl acetate, and an organic phase is distilled under pressure; step 2, (E)-3-(5-formyl-1-methyl-1H-pyrrole-2-yl)ethyl acrylate is synthesized; step 3, a compound 5 is synthesized; step 4, a compound 6 is synthesized; step 5, MC-1568 is synthesized. By means of the synthesis method, purification in traditional technologies is avoided, and industrialization can be realized.
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- COMPOSITIONS AND METHODS FOR TREATING EPIGENETIC DISEASE
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The present disclosure provides compounds and compositions capable of treating cancer or an autoimmune disease, such as Crohn's disease, and methods of use thereof.
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- Improved synthesis and structural reassignment of MC1568: A class IIa selective HDAC inhibitor
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An improved synthesis and structural reassignment of the class IIa selective histone deacetylase (HDAC) inhibitor MC1568 are described.
- Fleming, Cassandra L.,Ashton, Trent D.,Gaur, Vidhi,McGee, Sean L.,Pfeffer, Frederick M.
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p. 1132 - 1135
(2014/03/21)
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