Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors
A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral bioavailability and efficacy in a tumor xenograft model.
Patel, Hitesh K.,Grotzfeld, Robert M.,Lai, Andiliy G.,Mehta, Shamal A.,Milanov, Zdravko V.,Chao, Qi,Sprankle, Kelly G.,Carter, Todd A.,Velasco, Anne Marie,Fabian, Miles A.,James, Joyce,Treiber, Daniel K.,Lockhart, David J.,Zarrinkar, Patrick P.,Bhagwat, Shripad S.
scheme or table
p. 5182 - 5185
(2010/03/31)
UREA DERIVATIVES AS KINASE MODULATORS
The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
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Page/Page column 155-216
(2008/06/13)
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