Heterologous expression of highly reducing polyketide synthase involved in betaenone biosynthesis
A unique highly reducing polyketide synthase (HR-PKS) with a reductase domain was identified in a betaenone biosynthetic gene cluster. Successful heterologous expression and characterization of the HR-PKS and trans-acting enoyl reductase (ER) provide insights into the core structure formation with a decalin scaffold and allow reconstitution of the betaenone biosynthetic machinery.
Stereoselctive synthesis of (-)-betaenone C through intramolecular Diels-Alder reaction has made possible to provide pertinent intermediates for the biosynthetic study of betaenones.
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