- Synthetic method of 4-chloro-2-(N-methyl-N-phenyl sulfamoyl) methyl benzoate
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The invention provides a synthetic method of 4-chloro-2-(N-methyl-N-phenyl sulfamoyl) methyl benzoate. The technical scheme is that 4-chloro-2-aminobenzoic acid is taken as a raw material and has an esterification reaction, a product is subjected to diazotization and the Sandmeyer reaction, methyl 4-chloro-2-(chlorosulfonyl)benzoate is prepared and subjected to condensation with N-methylaniline, and 4-chloro-2-(N-methyl-N-phenyl sulfamoyl) methyl benzoate is obtained. The synthetic method has the advantages of conciseness, high efficiency, mild conditions, no need of purification of an intermediate and simple operation, the total yield of three steps of reactions is as high as 65%, and the method is quite suitable for industrial production.
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Paragraph 0021; 0023
(2016/11/07)
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- A method for preparing the methyl two sulphur are prosperous (by machine translation)
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The invention discloses a method for synthesizing the methyl two sulphur are prosperous, belongs to the pesticide chemical field, the synthetic method is to 4 - chloro - 2 - aminobenzoic acid as the raw materials, by esterification, diazo, through sulfur dioxide, oxychloride, ammoniation ring, nitrogen methylation, carbonitriding, reduction, open-loop, a sulfonylation and condensation of the eleven step to make the methyl two sulphur are prosperous. The invention synthetic the methyl two sulphur are prosperous, the raw material is cheap, simple operation, mild condition, low equipment requirements, high yield, is suitable for industrial production, and the practicability is strong. (by machine translation)
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- A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS
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The present invention provides a compound having the structure (I) or a pharmaceutically acceptable salt or ester thereof.
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Page/Page column 128; 129
(2015/10/05)
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- Tricyclic benzoylpyrazole derivatives used as a herbicide
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Tricyclic benzoylpyrazole derivatives of the formula I wherein X, Y, R1, R2, R6, R7, R3, R4, R5, l, R8 and R9 are as defined in the disclosure and their agriculturally useful salts; processes and intermediates for preparing the tricyclic benzoylpyrazole derivatives; compositions comprising them and the use of these derivatives or of the compositions comprising them for controlling undesirable plants are described.
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Page/Page column 2
(2010/11/23)
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- Facile synthesis of 1, 2-benzisothiazole-3-one-1,1-dioxide methylsulfonyl derivatives
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An improved and general synthesis of saccharin methylthio and methylsulfone derivatives from chloro-substituted saccharins is presented. A large-scale procedure for preparation of chloro-substituted saccharins was developed. Treatment of the saccharin chlorides with sodium thiomethoxide and t-BuOK in DMF gave the saccharin methyl sulfides, which upon chromium(VI) oxide catalyzed oxidation with periodic acid afforded the corresponding saccharin methylsulfones in high yields.
- Xu, Liang,Trudell, Mark L.
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p. 435 - 438
(2007/10/03)
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- Tricyclic benzoylcyclohexanedione derivatives
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Tricyclic benzoylcyclohexanedione derivatives of the formula I where X, Y, R1, R2, R3, R4, R5, R9, and m are defined herein, and their agriculturally useful salts. Process for preparing the tricyclic benzoylcyclohexanedione derivatives; compositions comprising them and the use of these derivatives or of the compositions comprising them for controlling undesirable plants are described.
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- Endothelin receptor antagonists: Synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides
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The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure-activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ET(A) receptor subtype. Copyright (C) 1998 Elsevier Science Ltd.
- Berryman,Edmunds,Bunker,Haleen,Bryant,Welch,Doherty
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p. 1447 - 1456
(2007/10/03)
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