- Related substance of pyrazole compound, and preparation method and application of related substance
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The invention discloses a related substance of a pyrazole compound, and a preparation method and application of the related substance. The related substance is shown as the formula A. The preparation method of the related substance A comprises the followi
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Paragraph 0055; 0056
(2018/01/03)
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- Preparing method for pyrazole compound
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The invention discloses a preparing method for a pyrazole compound. The preparing method for the pyrazole compound is a method (1) or a method (2), wherein the method (1) includes the steps that a water solution of alkali is added into a water solution of
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Paragraph 0096-0117
(2017/08/30)
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- Detection and Treatment of Schizophrenia
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The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.
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- PROTEIN MODIFIER PRODUCTION INHIBITOR
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[PLOBLEMS] To provide a inhibitor of protein modification products formation capable of inhibiting of vitamin B6 deficiency disease as a side effect, especially a renal protective agent. [MEANS FOR SOLVING PROBLEMS] There is provided a use, as an active ingredient, of any of free or salt-form compounds of either of the formulae: (I) (II) [wherein R1 is substituted or unsubstituted aromatic ring; and each of R2, R3 and R4 is a hydrogen atom or monovalent organic group, or alternatively R2 and R3 cooperate to form a condensed ring or R3 and R4 cooperate to represent a divalent organic group, provided that R3 and R4 are not simulataneously hydrogen atoms].
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Page/Page column 17-18
(2008/06/13)
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