- 1-[(imidazolin-2-yl)amino]indoline and 1-[(imidazolin-2-yl)amino]1,2,3,4-tetrahydroquinoline derivatives: New insights into their circulatory activities
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N-[(Imidazolin-2-yl)amino]indolines and N-[(imidazolin-2-yl)amino]-1,2,3,4-tetrahydroquinolines, previously described in patent literature as hypertensive agents, were synthesized and tested in vitro for their affinities to α1- and α2-adrenoceptors as well as imidazoline I1 and I2 receptors. The compounds most potent at either α1- or α2-adrenoceptors were administered intravenously to normotensive Wistar rats to determine their effects on mean arterial blood pressure and heart rate. Upon intravenous administration at dose of 0.1 mg/kg to normotensive male Wistar rats, the initial transient pressor effect was followed by long-lasting hypotension and bradycardia. In view of the above results the 1-[(imidazolin-2-yl)amino]indolines and [(imidazolin-2-yl)amino]-1,2,3,4-tetrahydroquinolines are now found to possess circulatory profile characteristic of the centrally acting clonidine-like hypotensive imidazolines.
- S?czewski, Franciszek,Wasilewska, Aleksandra,Hudson, Alan L.,Ferdousi, Mehnaz,Rybczyńska, Apolonia,Boblewski, Konrad,Lehmann, Artur
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p. 277 - 287
(2015/04/22)
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- Synthesis of 1-amino-2-methylindoline by Raschig process: Parallel reactions, modeling, and optimization
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The reaction between chloramine and 2-methylindoline was studied at pH 12.89, T = 40°C, and for different initial concentrations of reactants. The interaction includes two concurrent bimolecular mechanisms leading to 1-amino-2-methylindoline and 2-methyli
- Elkhatib,Peyrot,Metz,Tenu,Elomar,Delalu
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p. 575 - 584
(2007/10/03)
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