- Novel compound 3-methyl-4,5-dichlorothiophene-2-carboxylic acid and preparation method thereof
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The invention discloses a novel compound 3-methyl-4,5-dichlorothiophene-2-carboxylic acid with the following structural formula defined in the specification. A preparation method of the compound 3-methyl-4,5-dichlorothiophene-2-carboxylic acid comprises the following steps: adding 3-methylthiophene-2-carboxylic acid into an acetic acid and N,N-dimethylformamide mixed solution, adding N-chlorosuccinimide in ice bath, and carrying out a reaction at the temperature of 25-35 DEG C for 4-6 h to obtain 3-methyl-4,5-dichlorothiophene-2-carboxylic acid. The synthetic route disclosed by the invention is short and only comprises one step, the used preparation method is simple to operate, the reaction is relatively mild, the product is easily treated and purified, and the preparation method is a method suitable for batch preparation. As such the compound is a valuable functional intermediate, the compound disclosed by the invention has important research and practical value, and the preparation and production of other similar derivatives can be greatly promoted.
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Paragraph 0010; 0016; 0017; 0018
(2019/01/08)
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