Selective C-C Bond Cleavage of Cycloalkanones by NaNO2/HCl
A novel selective fragmentation of cycloalkanones by NaNO2/HCl has been established. The C-C bond cleavage reaction proceeds smoothly under mild conditions, selectively affording versatile keto acids or oxime acids. The methodology can streamline the synthesis of valuable chiral molecules and isocoumarins from readily available feedstocks.
Solid-supported cross-metathesis and a formal alkane metathesis for the generation of biologically relevant molecules
Solid-phase synthetic strategies toward the generation of libraries of biologically relevant molecules were developed using olefin cross-metathesis as a key step. It is remarkably the formal alkane metathesis based on a one-pot, microwave-assisted, ruthenium-catalyzed cross-metathesis and reduction to obtain Csp3-Csp3 linkages.
Mndez, Luciana,Mata, Ernesto G.
p. 81 - 86
(2015/08/18)
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