Synthesis of 5,6-dihydrophenanthridines via N,O-acetal TMS ethers
A concise and high-yielding protocol for the synthesis of 5,6-dihydrophenanthridines is disclosed. The key feature includes a sequential reduction-cyclization reaction of N-acylcarbamates via N,O-acetal TMS ethers as a stable N-acyliminium ion precursor.
IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS
The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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(2010/04/28)
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