FUSED DIHYDROINDAZOLE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to fused dihydroindazole derivatives having pharmacological activity towards the α2δ subunit, in particular the α2δ subunit, of the voltage-gated calcium channel. It also relates to compounds having dual pharmacological activ
-
Page/Page column 74
(2020/02/14)
mu-OPIOID RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR AND USE THEREOF IN FIELD OF MEDICINE
Disclosed are a class of μ-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The μ-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.
-
Paragraph 0058; 0059
(2020/08/09)
Opioid receptor agonists and application thereof
The invention discloses compounds and salts thereof that can be used as opioid receptor ligands, a preparation method of the compounds, compositions containing the compounds, and a use of the compounds as [mu] opioid receptor agonists; the compounds are used for treatment of [mu] opioid receptor-mediated related diseases, such as pains and pain-related disorders.
-
Paragraph 0300; 0302-0306
(2019/01/24)
DEUTERATED COMPOUNDS FOR TREATING PAIN
The invention provides novel chemical compounds useful for treating pain or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
-
Paragraph 0086; 0087
(2018/02/28)
DEUTERATED COMPOUNDS FOR TREATING PAIN
The invention provides novel chemical compounds useful for treating pain or a related disease or disorder thereof, and pharmaceutical composition and methods of preparation and use thereof.
-
Paragraph 0052; 0053
(2017/07/06)
PYRANOPYRIDONE INHIBITORS OF TANKYRASE
There are provided compounds of the formula or a pharmaceutically acceptable salt thereof wherein X, M, Y, R1 and R2 are as defined herein. The compounds have activity as anticancer agents.
-
Page/Page column 41; 42; 43
(2014/01/09)
On the choice of Lewis acids for the Prins reaction; two total syntheses of (±)-Civet
While developing new variations of the Prins cyclisation reaction, the effect of the choice of Lewis acid on the outcome of the reaction and the product(s) has been investigated, yielding hitherto unseen dihydropyran products in the Prins cyclisation reac
Chio, Freda K.,Warne, Julie,Gough, Damien,Penny, Mark,Green, Sasa,Coles, Simon J.,Hursthouse, Mike B.,Jones, Peter,Hassall, Lorraine,McGuire, Thomas M.,Dobbs, Adrian P.
supporting information; experimental part
p. 5107 - 5124
(2011/07/31)
Cellulose-SO3H as a recyclable catalyst for the synthesis of tetrahydropyranols via prins cyclization
Tetrahydropyranols are prepared in good yields and with high cis-selectivity by means of the Prins cyclization using cellulose-sulfonic acid under mild reaction conditions. This is the first report on the preparation of tetrahydropyranols using epoxides and homoallylic alcohols via Prins cyclization.
Subba Reddy,Venkateswarlu,Narayana Kumar,Vinu
experimental part
p. 6511 - 6515
(2011/02/24)
The 'aqueous' Prins cyclization: A diastereoselective synthesis of 4-hydroxytetrahydropyran derivatives
Phosphomolybdic acid (H3PMo12O40, a heteropoly acid) is found to catalyze efficiently the Prins cyclization of homoallylic alcohols with aldehydes in water at room temperature to provide tetrahydropyran-4-ol derivatives in high yields with all cis-selectivity. Only cyclic ketones can give spirocyclic products. The use of phosphomolybdic acid in water makes this procedure simple, more convenient, cost-effective, and environmentally friendly. Georg Thieme Verlag Stuttgart.
Yadav, Jhillu S.,Subba Reddy, Basi V.,Narayana Kumar, Gunda G. K. S.,Aravind, Seema
p. 395 - 400
(2008/09/20)
More Articles about upstream products of 855398-58-2