- Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
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The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
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Paragraph 2297-2300
(2013/03/26)
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- TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION
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The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
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Page/Page column 154
(2012/03/10)
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- 4-AMINO-5-OXO-7, 8-DIHYDROPYRIMIDO [5,4-F] [1,4] OXAZEPIN-6 (5H) -YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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The invention provides compounds of Formula (I), wherein R1, R2a, R2b, R3, m and A are as defined herein, as well as compositions thereof and methods for treating a disease, condition or disorder that is modulated by the inhibition of the diacylglycerol O-acyltransferase 1 (DGAT-1) enzyme by administering the compounds of the present invention and/or compositions thereof.
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Page/Page column 47-48
(2010/08/09)
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- 4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES
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The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.
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Page/Page column 22
(2010/08/08)
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- Lipase-mediated asymmetric construction of 2-arylpropionic acids: Enantiocontrolled syntheses of S-naproxen and S-ibuprofen
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A general and enantiocontrolled synthetic route to 2-arylpropionic acids, represented by non-steroidal anti-inflammatory drugs S-naproxen 1a and S-ibuprofen 1b, has been developed by employing the lipase-mediated asymmetric acetylation of prochiral 2-aryl-1,3-propanediol 3, which has been derived via a Heck reaction, as the key step.
- Bando, Toshikazu,Namba, Yukiko,Shishido, Kozo
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p. 2159 - 2165
(2007/10/03)
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