New enantioselective synthesis of 4-hydroxy-2-oxopyrrolidine-N-acetamide (oxiracetam) from malic acid
The enantioselective synthesis of oxiracetam has been accomplished from readily available optically active D(+) and L(-) malic acids. the key step of the described method involves the selective reduction of a chiral cyclic diimide; in this way, both enantiomers of 4-hydroxy-2-oxopyrrolidine-N-acetamides were prepared.
Almeida,Anaya,Martin,Grande,Moran,Cruz Caballero
p. 1431 - 1440
(2007/10/02)
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