- A oxiracetam key intermediate 2 - (2, 4 - dioxo-pyrrolidine - 1 - yl) - acetamide synthesis process
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The invention provides a novel synthesis process for preparing an oxiracetam key intermediate 2-(2,4-dioxopyrrolidine-1-yl)-acetamide by using 4-halogenated acetoacetic ester and glycinamide hydrochloride as raw materials by virtue of a 'one-pot method'. The novel synthesis process has the advantages of being few in reaction steps, high in yield, cheap and easily available in raw materials, simple in post-treatment, has few waste gas, waste water and waste residues and the like.
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Paragraph 0020; 0021
(2017/08/25)
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- A oxiracetam intermediate and its preparation method and application
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The invention provides an oxiracetam intermediate as well as a preparation method and application thereof. The oxiracetam intermediate is a solid or a crystalline solid, low in preparation cost, and easy to purify and store, and can be used for efficiently preparing oxiracetam. The structural formula is as shown in the specifications.
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Paragraph 0152-0155
(2017/08/31)
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- New enantioselective synthesis of 4-hydroxy-2-oxopyrrolidine-N-acetamide (oxiracetam) from malic acid
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The enantioselective synthesis of oxiracetam has been accomplished from readily available optically active D(+) and L(-) malic acids. the key step of the described method involves the selective reduction of a chiral cyclic diimide; in this way, both enantiomers of 4-hydroxy-2-oxopyrrolidine-N-acetamides were prepared.
- Almeida,Anaya,Martin,Grande,Moran,Cruz Caballero
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p. 1431 - 1440
(2007/10/02)
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