PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
The invention provides a combination comprising an ancillary compound (e.g. one, two or more ancillary compounds) and a compound of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing f
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(2010/07/08)
Identification of inhibitors of protein kinase B using fragment-based lead discovery
Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 μM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand effi
Saxty, Gordon,Woodhead, Steven J.,Berdini, Valerio,Davies, Thomas G.,Verdonk, Marcel L.,Wyatt, Paul G.,Boyle, Robert G.,Barford, David,Downham, Robert,Garrett, Michelle D.,Carr, Robin A.
p. 2293 - 2296
(2008/02/05)
PHARMACEUTICAL COMPOUNDS
The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length
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Page/Page column 82-83
(2010/11/25)
PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
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Page/Page column 108
(2010/02/12)
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