The present invention relates generally to inhibitors of the kinases, such as GSK-3, and more particularly to fused pyrimidine compounds.
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Page/Page column 30
(2010/02/12)
4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and selective glycogen synthase kinase-3 inhibitors
Modeling studies of a furo[2,3-d]pyrimidine GSK-3 hit compound 1 superimposed onto the X-ray crystal structure of a legacy pyrazolo[3,4-c] pyridazine GSK-3 inhibitor 2 led to the identification of 4-acylamino-6- arylfuro[2,3-d]pyrimidine template 3. Synth
Maeda, Yutaka,Nakano, Masato,Sato, Hideyuki,Miyazaki, Yasushi,Schweiker, Stephanie L.,Smith, Jeffery L.,Truesdale, Anne T.
p. 3907 - 3911
(2007/10/03)
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