- HETEROCYCLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE
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Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): (wherein X1 to X4 represent a carbon atom, etc., ring A represents a 5- or 6-membered heteroaryl having from 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom, X5 represent an oxygen atom, etc., X represent a carbon atom, etc., Het represents a 5- or 6-membered aliphatic hetero ring, R1 represents aryl, etc., R2 represents formyl, etc., R3 represents -C1-6 alkyl, etc.), as well as their pharmaceutically acceptable salts.
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Page/Page column 58
(2010/11/30)
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- Methanesulfonylation of deactivated aromatics with superelectrophilic CH3so2F·3SbF5 and (CH3so2)2O-2CF3so 3H/B(O3SCF3)3 systems
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Methanesulfonylation of various deactivated arenes, including tri- and tetrafluorobenzenes, was achieved in good yield under mild conditions using superelectrophilic CH3SO2F/3SbF5 and (CH3SO2O)2O/2CF3SO 3H-B(O3SCF3)3 reagent systems. 1998 MAHK "Hayka/Interperiodica".
- Olah,Orlinkov,Oxyzoglou,Prakash, G.K. Suria
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p. 1573 - 1578
(2007/10/03)
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- Herbicidal compounds and compositions containing them
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Herbicides of formula: STR1 in which: n=0,1, 2 f=0,1 A is chosen from the groups STR2 in which: Ar is chosen from the groups STR3 B is chosen from optionally substituted C1 -C10 alkyl and C3 -C10 cycloalkyl grou
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- The Friedel-Crafts Type Methanesulfonylation of Deactivated Benzenes
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The participation of nonionic donor-acceptor complex was suggested by the analyses of product isolated in the Friedel-Crafts reaction of m-dichlorobenzene with CH3SO2Cl in the presence of AlCl3.On the basis of these observations a new practical method of methanesulfonylation of deactivated benzenes employing methanesulfonic anhydride and CF3SO3H was developed.
- Ono, Mitsunori,Nakamura, Yoshisada,Sato, Shingo,Itoh, Isamu
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p. 395 - 398
(2007/10/02)
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