- New tetrahydropyrido pyrimidinecarboxylic compound or salt thereof
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To provide a compound having an inhibitory activity for an androgen receptor. A tetrahydropyridopyrimidine compound represented by the following general formula (I) or a pharmaceutically acceptable thereof (in the formula, X and R are as defined in the specification).
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Paragraph 0159
(2016/10/08)
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- Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists
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Utilization of a tetrahydro-pyrimdoazepine core as a bioisosteric replacement for a piperazine-urea resulted in the discovery a novel series of potent antagonists of TRPV1. The tetrahydro-pyrimdoazepines have been identified as having good in vitro and in
- Hawryluk, Natalie A.,Merit, Jeffrey E.,Lebsack, Alec D.,Branstetter, Bryan J.,Hack, Michael D.,Swanson, Nadia,Ao, Hong,Maher, Michael P.,Bhattacharya, Anindya,Wang, Qi,Freedman, Jamie M.,Scott, Brian P.,Wickenden, Alan D.,Chaplan, Sandra R.,Breitenbucher, J. Guy
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scheme or table
p. 7137 - 7141
(2010/12/25)
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- BICYCLOHETEROARYLAMINE COMPOUNDS AS ION CHANNEL LIGANDS AND USES THEREOF
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Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, includin
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Page/Page column 106
(2010/02/12)
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- Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
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Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
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