- Preparation method of 4-acetoxy-2-methyl-2-butenal
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The invention discloses a preparation method of 4-acetoxy-2-methyl-2-butenal, which takes salifying and wittig reactions as a core and methanol which is cheap and easy to obtain as a reaction initial raw material. The invention provides a new reaction route, the reaction steps are simple, the reaction conditions are mild, and the product yield is high.
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Paragraph 0013; 0042-0044; 0052-0054; 0062-0064; 0072; ...
(2021/09/04)
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- Antiviral combination comprising nucleoside analogs
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Antiviral and antitumor compositions are disclosed comprising a mixture of AZT, ribavirin, d4T or CS-87 with a compound of general formula: STR1 wherein Z is H, OH or NH2, Y is CH, and X is selected from the group consisting of H, N(R)2, SR, OR or halogen, wherein R is H, lower(C1 -C4)alkyl, aryl or mixtures thereof, and the pharmaceutically-acceptable derivatives thereof.
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- Optically-active isomers of dideoxycarbocyclic nucleosides
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Antiviral and antitumor compounds are disclosed of general formula: STR1 wherein Z is H, OR' or NH2, wherein R' is H, (C1 -C4)alkyl, aryl, CHO, (C1 -C16)alkanoyl or O=P(OH)2, Y is CH or N, and X is selected from the group consisting of H, N(R2), SR, OR' or halogen, wherein R is H, lower(C1 -C4)alkyl, aryl or mixtures thereof, and the pharmaceutically-acceptable salts thereof.
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- Optically-active isomers of dideoxycarbocyclic nucleosides
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Antiviral and antitumor compounds are disclosed of general formula: STR1 wherein Z is H, OR' or NH2, wherein R' is H, (C1 -C4)-alkyl, aryl, CHO, (C1 -C16)alkanoyl or O=P(OH)2, Y is CH or N, and X is selected from the group consisting of H, N(R2), SR, OR' or halogen, wherein R is H, lower-(C1 -C4)alkyl, aryl or mixtures thereof, and the pharmaceutically-acceptable salts thereof.
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