- DIENAMINES AS DIELS-ALDER DIENES. A NOVEL BENZANNULATION SEQUENCE.
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Diels-Alder reaction between (E)-dienamines 1-7 and methyl propiolate followed by elimination of Me2NH from the intermediate cycloadducts III affords the aromatic methyl esters 8-14 in good yield.
- Snowden, Roger L.,Wust, Manfred
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- Efficient synthesis of 9,10-dihydrophenanthrene and 6H-benzo[c]chromene derivatives via 6π electrocyclization
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An efficient and very simple method has been developed for the synthesis of 9,10-dihydrophenanthrene, 6H-benzo[c]chromene and various types of bicyclic benzenoid derivatives via 6π-electron electrocyclization reaction, followed by deacetylation.
- Dhara, Shubhendu,Gorai, Tumpa,Ahmed, Atiur,Ray, Jayanta K.
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p. 1675 - 1679
(2014/01/17)
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- Synthesis of substituted benzenes and phenols by ring-closing olefin metathesis
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New synthetic approaches to substituted aromatic compounds are reported. Ring-closing olefin metathesis (RCM)/dehydration and RCM/tautomerization are the key processes in the synthesis of substituted benzenes 3 and phenols 6, respectively. Readily accessible 1,5,7-trien-4-ols 7, which are the precursors of benzenes, were prepared from β-halo-α, β-unsaturated aldehydes 11 or β-halo-α,β-unsaturated esters 19 by utilizing reliable transformations in which cross-coupling with vinylic metal reagents 12 and allylation with allylic metal reagents 13 were employed as carbon-carbon bond forming reactions. RCM of 7, followed by dehydration, afforded a wide variety of substituted benzenes 3. In addition, RCM of 1,5,7trien-4-ones 9, which were prepared by oxidation of 7, furnished various substituted phenols 6 by automatic tautomerization.
- Yoshida, Kazuhiro,Takahashi, Hidetoshi,Imamoto, Tsuneo
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experimental part
p. 8246 - 8261
(2009/09/29)
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- HCV PROTEASE INHIBITORS
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This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
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Page/Page column 40
(2008/12/07)
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- Syntheses of compounds active toward glutamate receptors: I. New preparative synthesis of aminoindandicarboxylic acid (AIDA)
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A preparative procedure has been developed for the synhtesis of 1-aminoindan-1,5-dicarboxylic acid which is a new group I metabotropic glutamate receptor antagonist.
- Matveeva,Podrugina,Zefirova,Alekseev,Bachurin,Pellicciari,Zefirov
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p. 1764 - 1768
(2007/10/03)
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- Aromatic Spiranes, XIV: Syntheses of 2,2'-Spirobi-(s-hydrindacene) and its precursors
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The title compound 35 was prepared by catalytic reduction of the diones 29a and 11a. 29a was synthesized by systematic anellation of fivemembered rings to the positions 5,6 and 5',6', resp., of 2,2'-spirobiindane.The preparation of 11a was achieved by Friedel-Crafts cyclisation of bis-(5-indanylmethyl)-malonic acid. s-Hydrindacene-1-one 5a was prepared as a precursor for the synthesis of 11a (see forthcoming publication) and its derivates as models for corresponding anellation and substitution reactions. - Keywords: s-Hydrindacene-1-one and derivates; Mono- and bisanellation; 2,2'-Spirobiindane; 1H-nmr spectra
- Neudeck, Horst K.
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p. 627 - 658
(2007/10/02)
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