Further Synthetic Studies in Penicillin C(6)-Substitution Including the Versatile 6&α-Succinimidooxy Leaving Group
Treatment of benzyl 6α-dimethylamino-6β-phenoxyacetamidopenicillanate 3 with methyl iodide led, in the absence of added nucleophiles, to the oxygen-bridged dimer 8 via adventitious water present.Added methanol or water led to the 6α-methoxy or -hydroxy pr
Milner, Peter H.,Stachulski, Andrew V.
p. 2343 - 2352
(2007/10/02)
Penicillin C-6 Substitution using the Versatile 6α-Succinimido-oxy Leaving Group
Reaction of benzyl 6α-(methylthio)-6β-(phenoxyacetamido)penicillanate with N-hydroxysuccinimide catalysed by silver(I) acetate afforded the stable 6α-(succinimido-oxy) derivative; this species on reaction with various nucleophiles gave a range of 6α-subst
Stachulski, Andrew V.
p. 401 - 402
(2007/10/02)
Process for the preparation of β-lactam compounds
A process for the preparation of a β-lactam having the partial structure (I): STR1 wherein R1 is an acyl group, which process comprises treating an imine having the partial structure (II): STR2 with a nucleophilic derivative of formamide.
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(2008/06/13)
6&α(7&α)-Formamido Penicillins and Cephalosporins
6α(7α)-(Methylthio)penicillins and cephalosporins have been converted into novel antibacterially active 6α(7α)-formamido derivatives by using either mercury(II) acetate and ammonia followed by formylation, or mercury(II) acetate and N,N-bis(trimethylsilyl
Milner, Peter H.,Guest, Angela W.,Harrington, Frank P.,Ponsford, Roger J.,Smale, Terence C.,Stachulski, Andrew V.
p. 1335 - 1336
(2007/10/02)
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