cas 861340-10-5, 1H-Indazole-4-carbonitrile | Articles data ｜lookchem

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861340-10-5

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OXADIAZOLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF
PROBLEM TO BE SOLVED: To provide therapeutic or preventive agents for various diseases or symptoms associated with a serotonin 4 receptor (particularly, neuropsychiatric diseases such as Alzheimer-type dementia). SOLUTION: The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. In the formula (1), Het represents formula (Het-1) or the like, A represents formula (A-1) or the like, B represents (B-1) or the like, R1A represents a hydrogen atom, an alkyl group or the like, R2A, R5, R6 and R7 represent a hydrogen atom, a halogen atom, an alkyl group or the like, R8 and R9 represent a hydrogen atom, an alkyl group or the like, and l represents an integer of 0-4. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0286-0287

(2017/02/02)

SERINE/THREONINE PAK1 INHIBITORS
Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.
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Page/Page column 111

(2013/03/26)

3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR
Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein, pharmaceutical compositions containing them and methods of using them for the preparation of medicaments for treating depression or anxiety.
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Page/Page column 102-103

(2010/02/15)

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Chemical Properties

Melting Point: 157-160 °C(Solv: ligroine (8032-32-4))
Boiling Point: 370.3 °C at 760 mmHg
Flash Point:126.7 °C
Density: 1.33 g/cm³
Storage Temp.:2-8°C(protect from light)
Vapor Pressure: 1.12E-05mmHg at 25°C
Refractive Index: 1.684
PKA: 11.61±0.40(Predicted)
PSA: 52.47000
LogP: 1.43458

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