Process for the synthesis of sulfonyl halides and sulfonamides from sulfonic acid salts
The present invention provides synthetic processes for the preparation of sulfonyl halides of Formula Ar—(R)z—O2—X and sulfonamides of Formula Ar—(R)2—SO2—NR4R5, where the constituent varia
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(2008/06/13)
INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLAα). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.
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(2008/06/13)
Processes for the preparation of aryl-and heteroaryl-alkylsulfonyl halides
The present invention provides processes for the preparation of arylalkylsulfonyl halides and heteroarylalkylsufonyl halides of Formula I: Ar—R—SO2—X, that are useful as intermediates in the preparation of pharmaceuticals.
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(2008/06/13)
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