STRUCTURAL ELUCIDATION OF EPALRESTAT(ONO-2235), A POTENT ALDOSE REDUCTASE INHIBITOR, AND ISOMERIZATION OF ITS DOUBLE BONDS
The structure of epalrestat (ONO-2235) is revised by X-ray single crystal analysis.The structures of the photoisomers are proposed on the basis of NMR and UV spectroscopic evidences.
Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient
The rhodanine derivatives of the general formula: STR1 wherein (I) R1 and R2 are taken together to represent a tetramethylene or pentamethylene group; (II) R1 represents a hydrogen atom, and R2 represents (1) a
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(2008/06/13)
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