Regioselective synthesis of 2-amino-isophthalonitriles through a ring transformation strategy
An expeditious synthesis of several 2-amino-isophthalonitriles and their biaryl compounds is described and illustrated by carbanion-induced ring transformation of functionalized 2H-pyran-2-ones with malononitrile in excellent yields. The strength of the r
Arylanthranilodinitriles: A new biaryl class of antileishmanial agents
A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed
Regioselective synthesis of functionally congested biaryls through a novel C-C bond formation reaction
An expeditious synthesis of unsymmetrical biaryls functionalized with electron-withdrawing or -donating substituents is described and illustrated by the carbanion-induced ring transformation of 2H-pyran-2-ones with malononitrile in excellent yields.
Goel, Atul,Singh, Fateh Veer
p. 5585 - 5587
(2007/10/03)
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